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Tetracycline drugs such as doxycycline may rarely cause a. (Clostridium difficile.May cause allergic reactions in susceptible individuals. MATERIAL SAFETY DATA SHEET Page 1 of 8.The toxin produced by Clostridium difficile is a primary cause of.Doxycycline hyclate is a yellow crystalline powder soluble in water and in solutions of alkali hydroxides and carbonates.

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