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Doxycycline, a synthetic derivative of tetracycline,. but has greater bioavailability, a longer half-life, and a more favorable adverse effect profile.

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Doxycycline is a broad-spectrum tetracycline antibiotic available as hyclate, calcium and monohydrate salts.Pharmacokinetics of Oral Doxycycline during Combination Treatment of.

Half-life 15 to 24 hours 11 to 22 hours Protein binding 82% - 93% 76%.